This volume collect the proceedings of the ENC Enhancing Nature in Cities conference, organized within the framework of the PRIN PNRR GREENWORK research project “An interdisciplinary framework for urban health and urban resilience enhancement based on greening strategies on buildings and open spaces”. The collected contributions are structured around three main thematic areas: resilience to urban risks, urban microclimate and open spaces, and interventions at the building scale, offering an interdisciplinary and integrated perspective on the challenges and opportunities of the ecological transition in urban contexts.